PF 6274484

CAS No. 1035638-91-5

PF 6274484 ( —— )

Catalog No. M23243 CAS No. 1035638-91-5

PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 31 In Stock
5MG 50 In Stock
10MG 84 In Stock
25MG 177 In Stock
50MG 332 In Stock
100MG 494 In Stock
500MG 1071 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PF 6274484
  • Note
    Research use only, not for human use.
  • Brief Description
    PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM.
  • Description
    PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1035638-91-5
  • Formula Weight
    372.8
  • Molecular Formula
    C18H14ClFN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    COc(cc(c1c2)ncnc1Nc(cc1)cc(Cl)c1F)c2NC(C=C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

molnova catalog
related products
  • Beta-Hydroxyisovaler...

    Beta-Hydroxyisovalerylshikonin is an inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin significantly decreased viability of HCT116 cells (IC50 values = 30.9 μg/mL).

  • R162

    R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor.

  • PD 089828

    PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)